{"id":48510,"date":"2024-05-09T17:13:09","date_gmt":"2024-05-09T09:13:09","guid":{"rendered":"http:\/\/www.newtopchem.com\/archives\/48510"},"modified":"2024-05-09T17:13:09","modified_gmt":"2024-05-09T09:13:09","slug":"haloperidol","status":"publish","type":"post","link":"http:\/\/www.newtopchem.com\/archives\/48510","title":{"rendered":"haloperidol","gt_translate_keys":[{"key":"rendered","format":"text"}]},"content":{"rendered":"<p><img decoding=\"async\" loading=\"lazy\" class=\"alignnone size-full wp-image-48509\" src=\"http:\/\/www.newtopchem.com\/wp-content\/uploads\/2024\/05\/c94bea645c0f46a3b0e2c74b4acaac48.gif\" width=\"278\" height=\"232\" alt=\"Haloperidol structural formula\" \/><\/p>\n<p>Structural formula<\/p>\n<table class=\"summary-table table table-striped table-bordered\">\n<col width=\"90\" \/>\n<tbody>\n<tr>\n<th scope=\"row\">Business number<\/th>\n<td>015P<\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">Molecular formula<\/th>\n<td>C21H23ClFNO2<\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">Molecular weight<\/th>\n<td>375.86<\/td>\n<\/tr>\n<tr>\n<th scope=\"row\">label<\/th>\n<td>\n<p>                         haloperidol,<\/p>\n<p>                         halopyridol,<\/p>\n<p>                         1-(4-Fluorophenyl)-4-[4-(4-chlorophenyl)-4-hydroxy-1-piperidinyl]-1-butanone,<\/p>\n<p>                         iohexol,<\/p>\n<p>                         haloperidol,<\/p>\n<p>                         4-[4-(p-Chlorophenyl)-4-hydroxypiperidino]-4&#8242;-fluorobutyrophenone,<\/p>\n<p>                         4-[4-(4-Chlorophenyl)-4-hydroxy-1-piperidinyl]-1-(4-fluorophenyl)-1-butanone,<\/p>\n<p>                         4-[4-(4-Chlorophenyl)-4-hydroxypiperidino]-4&#8242;-fluorobut<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<ul class=\"nav nav-tabs\">\n<li class=\"active\"><a href=\"#bh\">Numbering system<\/a><\/li>\n<li><a href=\"#wx\">Physical property data<\/a><\/li>\n<li><a href=\"#dl\">Toxicological data<\/a><\/li>\n<li><a href=\"#st\">Ecological data<\/a><\/li>\n<li><a href=\"#fz\">Molecular structure data<\/a><\/li>\n<li><a href=\"#js\">Computing chemical data<\/a><\/li>\n<li class=\"dropdown pull-right\">\n                     <a href=\"\" class=\"dropdown-toggle\">More <span class=\"caret\"><\/span><\/a><\/p>\n<ul class=\"dropdown-menu\" role=\"menu\">\n<li><a href=\"#xz\">Properties and Stability<\/a><\/li>\n<li><a href=\"#zc\">Storage method<\/a><\/li>\n<li><a href=\"#hc\">Synthesis method<\/a><\/li>\n<li><a href=\"#yt\">Purpose<\/a><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<h2 id=\"bh\">Numbering system<\/h2>\n<p><b>CAS number:<\/b>52-86-8<\/p>\n<p><b>MDL number:<\/b>MFCD00051423<\/p>\n<p><b>EINECS number:<\/b>200-155-6<\/p>\n<p><b>RTECS number:<\/b>EU1575000<\/p>\n<p><b>BRN number:<\/b>None<\/p>\n<p><b>PubChem number:<\/b>24277917<\/p>\n<h2 id=\"wx\">Physical property data<\/h2>\n<p>\n     <P class=\"MsoNormal\" align=\"left\"><SPAN><SPAN>1.<SPAN> <\/SPAN><\/SPAN><\/SPAN>  <SPAN>Characteristics:  <\/SPAN><SPAN>  White or off-white crystalline powder.  Odorless and tasteless.  <\/SPAN><SPAN><\/SPAN><\/P><br \/>\n <P class=\"MsoNormal\" align=\"left\"><SPAN><SPAN>2.<SPAN> <\/SPAN><\/SPAN><\/SPAN>  <SPAN>Density (  <\/SPAN><SPAN>g\/mL,25\/4<\/SPAN><SPAN>\u2103\uff09\uff1a<\/SPAN><SPAN> <\/SPAN>Undetermined<\/SPAN><SPAN> <\/SPAN><SPAN><SPAN> <\/SPAN><SPAN>  SPAN&gt;<\/SPAN><SPAN><\/SPAN><\/P><br \/>\n <P class=\"MsoNormal\" align=\"left\"><SPAN><SPAN>3.<SPAN> <\/SPAN><\/SPAN><\/SPAN>  <SPAN>Relative steam  Density (<\/SPAN><SPAN>g\/mL,<\/SPAN><SPAN>AIR<\/SPAN><SPAN>=1<\/SPAN><SPAN>): Undetermined<\/SPAN><SPAN><\/SPAN><\/P><br \/>\n <P class=\"MsoNormal\" align=\"left\"><SPAN><SPAN>4.<SPAN> <\/SPAN><\/SPAN><\/SPAN>  <SPAN>Melting point (  <\/SPAN><SPAN>\u00baC<\/SPAN><SPAN>):<\/SPAN><SPAN>148-149.4<\/SPAN><SPAN><\/SPAN><\/P><br \/>\n <P class=\"MsoNormal\" align=\"left\"><SPAN><SPAN>5.<SPAN> <\/SPAN><\/SPAN><\/SPAN>  <SPAN>Boiling point (  <\/SPAN><SPAN>\u00baC,<\/SPAN><SPAN>Normal pressure): Undetermined<\/SPAN><SPAN><\/SPAN><\/P><br \/>\n <P class=\"MsoNormal\" align=\"left\"><SPAN><SPAN>6.<SPAN> <\/SPAN><\/SPAN><\/SPAN>  <SPAN>Boiling point (  <\/SPAN><SPAN>\u00baC, <\/SPAN><SPAN>  13.33kpa<\/SPAN><SPAN>): <\/SPAN><SPAN> <\/SPAN><SPAN><\/SPAN><\/P><br \/>\n <P class=\"MsoNormal\" align=\"left\"><SPAN><SPAN>7.<SPAN> <\/SPAN><\/SPAN><\/SPAN>  <SPAN>Refractive index:<\/SPAN><SPAN>  <\/SPAN><SPAN>Undetermined<\/SPAN><SPAN><\/SPAN><\/P><br \/>\n <P class=\"MsoNormal\" align=\"left\"><SPAN><SPAN>8.<SPAN> <\/SPAN><\/SPAN><\/SPAN>  <SPAN>Flashpoint  (<\/SPAN><SPAN>\u00baC<\/SPAN><SPAN>):<\/SPAN><SPAN> <\/SPAN><SPAN>Undetermined<\/SPAN><SPAN><\/SPAN><\/P><br \/>\n <P class=\"MsoNormal\" align=\"left\"><SPAN><SPAN>9.<SPAN> <\/SPAN><\/SPAN><\/SPAN>  <SPAN>Specific optical activity  Degree (<\/SPAN><SPAN>\u00ba,<\/SPAN><SPAN>\uff09\uff1a<\/SPAN><SPAN> <\/SPAN><SPAN>Undetermined<\/SPAN><SPAN><\/SPAN><\/P><br \/>\n <P class=\"MsoNormal\" align=\"left\"><SPAN><SPAN>10.<SPAN> <\/SPAN><\/SPAN><\/SPAN>  <SPAN>Spontaneous ignition point  or ignition temperature (<\/SPAN><SPAN>\u00baC<\/SPAN><SPAN>): Undetermined<\/SPAN><SPAN><\/SPAN><\/P><br \/>\n <P class=\"MsoNormal\" align=\"left\"><SPAN><SPAN>11.<SPAN> <\/SPAN><\/SPAN><\/SPAN>  <SPAN>Vapor Pressure  (<\/SPAN><SPAN>kPa,25\u00baC<\/SPAN><SPAN>):<\/SPAN><SPAN> <\/SPAN><SPAN>Undetermined<\/SPAN><SPAN><\/SPAN><\/P><br \/>\n <P class=\"MsoNormal\" align=\"left\"><SPAN><SPAN>12.<SPAN> <\/SPAN><\/SPAN><\/SPAN><SPAN>Saturation vapor pressure (  <\/SPAN><SPAN>kPa,60\u00baC<\/SPAN><SPAN>): <\/SPAN><SPAN>  <\/SPAN><SPAN>  Undetermined<\/SPAN><SPAN><\/SPAN><\/P><br \/>\n <P class=\"MsoNormal\" align=\"left\"><SPAN><SPAN>13.<SPAN> <\/SPAN><\/SPAN><\/SPAN>  <SPAN>Burning heat  (<\/SPAN><SPAN>KJ\/mol<\/SPAN><SPAN>): Undetermined<\/SPAN><SPAN><\/SPAN><\/P><br \/>\n <P class=\"MsoNormal\" align=\"left\"><SPAN><SPAN>14.<SPAN> <\/SPAN><\/SPAN><\/SPAN>  <SPAN>Critical temperature  (<\/SPAN><SPAN>\u00baC<\/SPAN><SPAN>): Undetermined<\/SPAN><SPAN><\/SPAN><\/P><br \/>\n <P class=\"MsoNormal\" align=\"left\"><SPAN><SPAN>15.<SPAN> <\/SPAN><\/SPAN><\/SPAN>  <SPAN>Critical Pressure  (<\/SPAN><SPAN>KPa<\/SPAN><SPAN>): Undetermined<\/SPAN><SPAN><\/SPAN><\/P><br \/>\n <P class=\"MsoNormal\" align=\"left\"><SPAN><SPAN>16.<SPAN> <\/SPAN><\/SPAN><\/SPAN>  <SPAN>Oil and water (  Octanol<\/SPAN><SPAN>\/<\/SPAN><SPAN>Log value of water) partition coefficient: Undetermined<\/SPAN><SPAN><\/SPAN><\/P><br \/>\n <P class=\"MsoNormal\" align=\"left\"><SPAN><SPAN>17.<SPAN> <\/SPAN><\/SPAN><\/SPAN>  <SPAN>Explosion limit (<\/SPAN><SPAN>%,V\/V<\/SPAN><SPAN>): Undetermined<\/SPAN><SPAN><\/SPAN><\/P><br \/>\n <P class=\"MsoNormal\" align=\"left\"><SPAN><SPAN>18.<SPAN> <\/SPAN><\/SPAN><\/SPAN>  <SPAN>Lower explosion limit  (<\/SPAN><SPAN>%,V\/V<\/SPAN><SPAN>): Undetermined<\/SPAN><SPAN><\/SPAN><\/P><br \/>\n <P class=\"MsoNormal\" align=\"left\"><SPAN><SPAN>19.<SPAN> <\/SPAN><\/SPAN><\/SPAN>  <SPAN>Solubility  \uff1a<\/SPAN><SPAN>Easily soluble in chloroform, methanol, acetone, benzene and dilute acid, solubility in water<\/SPAN><SPAN>1.4mg\/100ml<\/SPAN><SPAN>.  <\/SPAN><SPAN><\/SPAN><\/P>\n     <\/p>\n<h2 id=\"dl\">Toxicological data<\/h2>\n<p>\n     <SPAN>Moderately toxic, LD50 (rat, oral)<\/SPAN><SPAN>165mg\/kg<\/SPAN><SPAN>.  <\/SPAN>\n     <\/p>\n<h2 id=\"st\">Ecological data<\/h2>\n<p>\n     None yet\n     <\/p>\n<h2 id=\"fz\">Molecular structure data<\/h2>\n<p>\n     <P class=\"MsoNormal\" align=\"left\"><SPAN><SPAN>1. <SPAN> <\/SPAN><\/SPAN><\/SPAN><SPAN>Molar refractive index: <\/SPAN>  <SPAN>101.01<\/SPAN><\/P><br \/>\n <P class=\"MsoNormal\" align=\"left\"><SPAN><SPAN>2. <SPAN> <\/SPAN><\/SPAN><\/SPAN><SPAN>Molar volume (<\/SPAN><SPAN>m<SUP>3<\/SUP>\/mol<\/SPAN><SPAN>\uff09\uff1a<\/SPAN><SPAN>303.2<\/SPAN><\/P><br \/>\n <P class=\"MsoNormal\" align=\"left\"><SPAN><SPAN>3. <SPAN> <\/SPAN><\/SPAN><\/SPAN><SPAN>Isotonic specific volume<\/SPAN><SPAN>(90.2K)<\/SPAN><SPAN>\uff1a  <\/SPAN><SPAN>797.8<\/SPAN><\/P><br \/>\n <P class=\"MsoNormal\" align=\"left\"><SPAN><SPAN>4. <SPAN> <\/SPAN><\/SPAN><\/SPAN><SPAN>Surface Tension<\/SPAN><SPAN>(dyne\/cm)<\/SPAN><SPAN>\uff1a<\/SPAN><SPAN>47.9<\/SPAN><\/P><br \/>\n <P class=\"MsoNormal\" align=\"left\"><SPAN><SPAN>5. <SPAN> <\/SPAN><\/SPAN><\/SPAN><SPAN>Polarizability<\/SPAN><SPAN>(10-24cm<SUP>3<\/SUP>)<\/SPAN><SPAN>\uff1a<\/SPAN><SPAN>40.04<\/SPAN><\/P>\n     <\/p>\n<h2 id=\"js\">Compute chemical data<\/h2>\n<p><p>1. Reference value for hydrophobic parameter calculation (XlogP): None<\/P><\/p>\n<p>2. Number of hydrogen bond donors: 1<\/p>\n<p>3. Number of hydrogen bond acceptors: 4<\/p>\n<p>4. Number of rotatable chemical bonds: 6<\/p>\n<p>5. Number of tautomers: 2<\/p>\n<p>6. Topological molecule polar surface area 40.5<\/p>\n<p>7. Number of heavy atoms: 26<\/p>\n<p>8. Surface charge: 0<\/p>\n<p>9. Complexity: 451<\/p>\n<p>10. Number of isotope atoms: 0<\/p>\n<p>11. Determine the number of atomic stereocenters: 0<\/p>\n<p>12. Uncertain number of atomic stereocenters: 0<\/p>\n<p>13. Determine the number of chemical bond stereocenters: 0  <\/p>\n<p>14. Number of uncertain chemical bond stereocenters: 0<\/p>\n<p>15. Number of covalent bond units: 1<\/p>\n<\/p>\n<h2 id=\"xz\">Properties and stability<\/h2>\n<p>\n     None yet\n     <\/p>\n<h2 id=\"zc\">Storage method<\/h2>\n<p>\n     <P class=\"MsoNormal\"><SPAN>Should be sealed and stored away from light.  <\/SPAN><SPAN><\/SPAN><\/P>\n     <\/p>\n<h2 id=\"hc\">Synthesis method<\/h2>\n<p>\n     <P class=\"MsoNormal\"><SPAN>By<\/SPAN><SPAN>4-<\/SPAN><SPAN>p-chlorobenzene<\/SPAN><SPAN>-4-<\/SPAN><SPAN>hydroxy piper and<SPAN>\u03b3<\/SPAN><\/SPAN><SPAN>&#8211;<\/SPAN><SPAN>Chloro-p-fluorophenbutanone condensation  And get.  Intermediate<SPAN>\u03b3<\/SPAN><\/SPAN><SPAN>Chlorofluorobenzene is composed of fluorobenzene,<SPAN>\u03b3<\/SPAN><\/SPAN><SPAN>&#8211;<\/SPAN><SPAN>Produced from butyrolactone and thionyl chloride.<\/SPAN><SPAN><\/SPAN><\/P>\n     <\/p>\n<h2 id=\"yt\">Purpose<\/h2>\n<p>\n     <P class=\"MsoNormal\"><SPAN>Antipsychotic drugs, formerly known as strong tranquilizers, are mainly used to control schizophrenia and other patients with hallucinations, delusions,  Excitement, impulsiveness and other related diseases.  Haloperidol is mainly used to combat mania and hallucinations in acute and chronic schizophrenia. It has a significant effect on controlling excitement and agitation, but it is ineffective in treating depression and apathy in schizophrenia.  <\/SPAN><SPAN><\/SPAN><\/P>\n     <\/p>\n<p>     extended-reading:<a href=\"https:\/\/www.bdmaee.net\/tin-chloride-anhydrous%ef%bc%8ctiniv-chloride\/\">https:\/\/www.bdmaee.net\/tin-chloride-anhydrous%ef%bc%8ctiniv-chloride\/<\/a><\/br>extended-reading:<a href=\"https:\/\/www.newtopchem.com\/archives\/44543\">https:\/\/www.newtopchem.com\/archives\/44543<\/a><\/br>extended-reading:<a href=\"https:\/\/www.newtopchem.com\/archives\/44436\">https:\/\/www.newtopchem.com\/archives\/44436<\/a><\/br>extended-reading:<a href=\"https:\/\/www.bdmaee.net\/wp-content\/uploads\/2022\/08\/16.jpg\">https:\/\/www.bdmaee.net\/wp-content\/uploads\/2022\/08\/16.jpg<\/a><\/br>extended-reading:<a href=\"https:\/\/www.morpholine.org\/category\/morpholine\/3-morpholinopropylamine\/\">https:\/\/www.morpholine.org\/category\/morpholine\/3-morpholinopropylamine\/<\/a><\/br>extended-reading:<a href=\"https:\/\/www.newtopchem.com\/archives\/44261\">https:\/\/www.newtopchem.com\/archives\/44261<\/a><\/br>extended-reading:<a href=\"https:\/\/www.bdmaee.net\/wp-content\/uploads\/2016\/06\/NIAX-Catalyst-A-1.pdf\">https:\/\/www.bdmaee.net\/wp-content\/uploads\/2016\/06\/NIAX-Catalyst-A-1.pdf<\/a><\/br>extended-reading:<a href=\"https:\/\/www.bdmaee.net\/niax-dmdee-catalysts-di-morpholine-diethyl-ether-momentive\/\">https:\/\/www.bdmaee.net\/niax-dmdee-catalysts-di-morpholine-diethyl-ether-momentive\/<\/a><\/br>extended-reading:<a href=\"https:\/\/www.bdmaee.net\/butylmercaptooxo-stannane\/\">https:\/\/www.bdmaee.net\/butylmercaptooxo-stannane\/<\/a><\/br>extended-reading:<a href=\"https:\/\/www.newtopchem.com\/archives\/category\/products\/page\/89\">https:\/\/www.newtopchem.com\/archives\/category\/products\/page\/89<\/a><\/p>\n","protected":false,"gt_translate_keys":[{"key":"rendered","format":"html"}]},"excerpt":{"rendered":"<p>Structural formula Business number 015P Molecular formu&#8230;<\/p>\n","protected":false,"gt_translate_keys":[{"key":"rendered","format":"html"}]},"author":1,"featured_media":48509,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[6],"tags":[15218],"gt_translate_keys":[{"key":"link","format":"url"}],"_links":{"self":[{"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/posts\/48510"}],"collection":[{"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/comments?post=48510"}],"version-history":[{"count":0,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/posts\/48510\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/media\/48509"}],"wp:attachment":[{"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/media?parent=48510"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/categories?post=48510"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/tags?post=48510"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}