<\/p>\n
Structural formula<\/p>\n
17\u03b1-Ethyne-1,3,5-(10)-estrotriene-3,17\u03b2-diol,<\/p>\n
17\u03b1-Ethynyl-1,3,5(10)-estratriene-3,17\u03b2-diol<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n
CAS number:<\/b>57-63-6<\/p>\n
MDL number:<\/b>MFCD00003690<\/p>\n
EINECS number:<\/b>200-342-2<\/p>\n
RTECS number:<\/b>RC8925000<\/p>\n
BRN number:<\/b>2419975<\/p>\n
PubChem number:<\/b>24894585<\/p>\nPhysical property data<\/h2>\n
1. Properties: White to milky white crystalline powder. Odorless. <\/p>\n
2. Density (g\/mL, 25\/4\u2103): 1.1460<\/p>\n
3. Relative vapor density (g\/mL, air=1): Undetermined<\/p>\n
4. Melting point (\u00baC): 145-146\u2103 (hemihydrate). 182-184\u2103 (anhydrous)<\/p>\n
5. Boiling point (\u00baC, normal pressure): Undetermined<\/p>\n
6. Boiling point (\u00baC, 5.2kPa): Undetermined<\/p>\n
7. Refractive index: Undetermined<\/p>\n
8. Flash point (\u00baC): Undetermined<\/p>\n
9. Specific rotation (\u00ba): Undetermined<\/p>\n
10. Autoignition point or ignition temperature (\u00baC): Undetermined<\/p>\n
11. Vapor pressure (kPa, 25\u00baC): Undetermined<\/p>\n
12. Saturated vapor pressure (kPa, 60\u00baC): Undetermined<\/p>\n
13. Heat of combustion (KJ\/mol): Undetermined<\/p>\n
14. Critical temperature (\u00baC): Undetermined<\/p>\n
15. Critical pressure (KPa): Undetermined<\/p>\n
16. The logarithmic value of the oil-water (octanol\/water) partition coefficient: Undetermined<\/p>\n
17. Explosion upper limit (%, V\/V): Undetermined<\/p>\n
18. Lower explosion limit (%, V\/V): Undetermined<\/p>\n
19. Solubility: Soluble in ethanol\ufffd\ufffd, propanol, ether, chloroform, dioxane, vegetable oil and sodium hydroxide solution are almost insoluble in water. <\/p>\n<\/p>\n
\n None\n <\/p>\n
1. Molar refractive index: 86.26<\/p>\n
2. Molar volume (m3\/mol): 244.4<\/p>\n
3. Isotonic specific volume (90.2K): 672.4<\/p>\n
4. Surface tension (dyne\/cm): 57.2<\/p>\n
5. Polarizability (10-24cm3): 34.19<\/p>\n<\/p>\n
1. Reference value for calculating hydrophobic parameters (XlogP): 3.7<\/p>\n
2. Number of hydrogen bond donors: 2<\/p>\n
3. Number of hydrogen bond receptors: 2<\/p>\n
4. Number of rotatable chemical bonds: 7<\/p>\n
5. Number of tautomers: 9<\/p>\n
6. Topological molecular polar surface area (TPSA): 40.5<\/p>\n
7. Number of heavy atoms: 22<\/p>\n
8. Surface charge: 0<\/p>\n
9. Complexity: 505<\/p>\n
10. Number of isotope atoms: 0<\/p>\n
11. Determine the number of atomic stereocenters: 5<\/p>\n
12. Number of uncertain atomic stereocenters: 0<\/p>\n
13. Determine the number of stereocenters of chemical bonds: 0<\/p>\n
14. Number of uncertain chemical bond stereocenters: 0<\/p>\n
15. Number of covalent bond units: 1<\/p>\n<\/p>\n
Stored in inert gas. <\/p>\n<\/p>\n
Obtained from the ethynylation of estrone (C18H22O2, [53-16-7]): Heat toluene isobutanol, potassium hydroxide and isobutanol under reflux and azeotropic dehydration for 8 hours, add tetrahydrofuran, and heat at 25-40\u00b0C Pour acetylene down to the required amount. Add estrone solution in tetrahydrofuran and continue to pass acetylene at 5-10\u00b0C for 12 hours. Use 30% sulfuric acid to adjust the slight acidity below 40\u00b0C, and recover tetrahydrofuran under reduced pressure. Remove the residual solution by steam distillation, cool, filter, wash with water until neutral, and dry at 80\u00b0C to obtain crude ethinyl estradiol. After recrystallization from ethanol and decolorization of activated carbon, the finished product is obtained. The yield is 85%. \n <\/p>\n<\/p>\n
This product is an estrogen drug. It has the same effect as diethylstilbestrol, but is 20 times more potent. Used in combination with progestin-based contraceptives, it has a synergistic effect in inhibiting ovulation, can enhance contraceptive efficacy, and can reduce side effects such as breakthrough bleeding. In addition, it can also be used for menstrual disorders such as amenorrhea, oligomenorrhea, menopausal syndrome and uterine hypoplasia. For preparation of contraceptive pills. <\/p>\n<\/p>\n
extended-reading:https:\/\/www.newtopchem.com\/archives\/44123<\/a><\/br>extended-reading:https:\/\/www.bdmaee.net\/wp-content\/uploads\/2022\/08\/potassium-acetate-CAS-127-08-2-Potassium.pdf<\/a><\/br>extended-reading:https:\/\/www.newtopchem.com\/archives\/1859<\/a><\/br>extended-reading:https:\/\/www.newtopchem.com\/archives\/44564<\/a><\/br>extended-reading:https:\/\/www.newtopchem.com\/archives\/category\/products\/page\/163<\/a><\/br>extended-reading:https:\/\/www.cyclohexylamine.net\/polyurethane-thermal-catalyst-thermal-delayed-catalyst\/<\/a><\/br>extended-reading:https:\/\/www.bdmaee.net\/pc-cat-np50-catalyst-pentamethyldipropylenetriamine\/<\/a><\/br>extended-reading:https:\/\/www.bdmaee.net\/dabco-mp601-catalyst-cas1739-84-0-evonik-germany\/<\/a><\/br>extended-reading:https:\/\/www.bdmaee.net\/fascat-4210-catalyst\/<\/a><\/br>extended-reading:https:\/\/www.bdmaee.net\/wp-content\/uploads\/2021\/05\/2-8.jpg<\/a><\/p>\n","protected":false,"gt_translate_keys":[{"key":"rendered","format":"html"}]},"excerpt":{"rendered":"Structural formula Business number 018U Molecular formu…<\/p>\n","protected":false,"gt_translate_keys":[{"key":"rendered","format":"html"}]},"author":1,"featured_media":49533,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[6],"tags":[15501],"gt_translate_keys":[{"key":"link","format":"url"}],"_links":{"self":[{"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/posts\/49534"}],"collection":[{"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/comments?post=49534"}],"version-history":[{"count":0,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/posts\/49534\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/media\/49533"}],"wp:attachment":[{"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/media?parent=49534"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/categories?post=49534"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/tags?post=49534"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
Structural formula Business number 018U Molecular formu…<\/p>\n","protected":false,"gt_translate_keys":[{"key":"rendered","format":"html"}]},"author":1,"featured_media":49533,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[6],"tags":[15501],"gt_translate_keys":[{"key":"link","format":"url"}],"_links":{"self":[{"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/posts\/49534"}],"collection":[{"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/comments?post=49534"}],"version-history":[{"count":0,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/posts\/49534\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/media\/49533"}],"wp:attachment":[{"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/media?parent=49534"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/categories?post=49534"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.newtopchem.com\/wp-json\/wp\/v2\/tags?post=49534"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
![\"Ethinyl](\"http:\/\/www.newtopchem.com\/wp-content\/uploads\/2024\/06\/44863adf2cbb49129efa4806b90e5658.gif\")
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